Molecualr Neurobiology Main Page>Introduction>Amygdala, Hippocampus,
Cerebellum>Hippocampus
Hippocampus
- Remember where to put your tooth brush back? Your Hippo
is working.
Hippocampus is a
part of the system called limbic
system and received highly processed information from all of
sensory
systems. Hippocampus is the first place where neuronal plasticity
was observed in vivo by Bliss and Lomo.
The neuronal plasticity is called long-term potentiation (LTP) that is
the activity-dependent enhancement of neuronal transmission.
Since
the discovery of LTP, hippocampus attract a major attention of
researchers in the field
of learning and memory.
The current
knowledge on hippocampal
roles in memory is its involvement of consolidation of memory, i.e.,
processing of short-term declarative memory into long-term one.
Bilateral
lobectomy of hippocampus to treat severe epileptic
seizure is reported in
human. After the lobectomy (removal) of medial temporal lobe, the
patient (H.M.) suffers severe anterograde amnesia
with
normal memories of his child days. As long as repeating the fact,
he can remember it (short-term memory), but when his attention is
distracted he immediately lose his memory. He even didn't
remember what he was doing. He reads same magazine
repeatedly without noticing he had read it. He brushes teeth but
he can not remember where his toothbrush was. Interestingly, H.M.
shows normal ability to learn skills, movement of body (non-declarative
memories).
The symptoms
observed in H.M. tell us important
roles
of hippocampus and features of memory:
1) Short-term memory doesn't
requires hippocampus,
2) Rehearsal (repeating) and
attention are required for shor-term
memory,
3) Recollection of past memory such
as childhood memory doesn't require
hippocampus,
4) Childhood memory is not stored
in hipocampus
5) Declarative memories requires
hippocampus
6) Non-declarative memories are
dealt with other part of the brain
Molecualr Neurobiology Main Page