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Cerebellum>Cerebellum
Cerebellum
- We move, the cerebellum is on the move.
Cerebellum means a little brain and much smaller
that cerebral cortex in many animals. In human the cerebellum has
only 1/10 volume of cerebral cortex. However, the cerebellum
contains more neurons than cerebral cortex. So, the cerebellum is
one of the most densely neuron-populated area in the central nervous
system.
The role of the
cerebellum is described in patients
in injury in the cerebellum such as gun-shot wound. A wound
caused by a bullet used to damage a large part of the brain.
However, the development of "rifle" gun allow a bullet to go straight
and injury become significantly smaller in bullet's in and out of the
body. The wound to the cerebellum didn't cause the
paralysis. However, caused ataxia, a loss of the
coordination of muscle movements. The patient has difficulty in
the coordinated movements of limbs such as clapping hands, walking,
balancing the body. Also have the problems in eye
movements. These patient have a problems in the test such as
finger-to-nose test. In addition, the patients with cerebellar
injury has difficulties in non-declarative memories. However,
declarative memories are intact.
The world-first
neuronal plasticity that shows the
"reduction" of neuronal transmission (long-term depression, LTD) is
observed in cerebellum by Dr. Masao Ito of Tokyo University based on
the mathematical models described by Albus and Marr. Simple
neuronal circuit of cerebellum and its clear role in motor coordination
and motor learning attract researchers. The
molecular mechanisms underlying cerebellar LTD is well studied.
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